Lecture

  • Infancy through childhood
    • Can children learn before birth? How?
    • What kind of Memory do infants have?
    • What is the language learning sensitive/critical period?
      • Before 12 years of age, after lose the ability to master due to phonetic discriminations
    • What is the difference between children language learning and adult language learning
      • Children: learn and categories from exposure, gradually categories exposed inputs
      • Adult: apply predisposed categories based on previous experience
  • Adolescent, adulthood, old age
    • What is the developmental feature for adolescence? Why?
      • WM and central executive function
      • Synaptic changes: strong synaptogenesis in Frontal Lobe, pruning throughout adulthood
      • Myelination: not complete until around 18, especially for frontal cortex
      • Modulation: increase in dopamine inputs from the midbrain to frontal cortex
    • What is the manifestation of age in brain?
      • Brain deterioration
      • Decrease neuronal density, synaptic density, moss of brain matter
      • Loss is uneven, frontal cortex show substantial loss
  • Genetic basis of learning and memory
    • Tyron Rats
      • Restricted: both poor
      • Normal: significant gap due to intelligence differences
      • Enriched: tiny gap due to intelligence differences
    • Epigenetic: G
      • Gene “turn on” due to environmental canges
  • Addiction
    • Definitions
      • Addiction: strong habit (compulsion) that is maintained despite known harmful consequences
      • Drug abuse ≠ addiction (depend on legality and dose)
    • How did addiction turn into comulsive
      • Reinforcement
        • Must have had a high level of positive reinforcement while taking it the first time
        • Incentive Salience:
          • Dopamine may be the physiological basis for “wanting” or “motivation”
          • Drug addiction to be excessive amplification specifically of psychological ‘wanting’, especially triggered by cues, without necessarily an amplification of ‘liking’
        • Biological
          • Addictive drugs all lead to increased DA release in the nucleus accumbens (ventral striatum)
      • Tolerance
        • Tolerance: reduced reaction to drug, so that larger doses are required to achieve original effect
        • Habituation: links between what happens in the brain during habituation and what happens through tolerance
        • Operant Conditioning: Experienced crack cocaine users show conditioned compensatory response to placebo crack
          • Conditioned compensatory response
            • A CR that is the opposite of the UR
            • Automatic response that is opposite to the effect of alcohol or substance usage.
      • Withdrawal
        • Withdraw: After taking a drug for a prolonged period of time (whether addicted to that drug or not), a period of withdrawal occurs, during which the opposite effects of the drug are experienced
        • Negative reinforcement associated with continued use to avoid withdrawal